Sports Betting
Sports Betting OffersNFL BettingCollege Football BettingNBA BettingCollege Basketball BettingSoccer BettingLegal States for Betting SportsLegal Sportsbooks for Betting Sports
Online Casinos
Casino OffersCasino NewsBlackjack strategyPoker strategyVideo PokerRoulette strategySlots strategyClassic SlotsBacarrat strategy
Betting Odds & Lines
NFL OddsCollege Football OddsNBA OddsCollege Basketball OddsNHL OddsSoccer OddsGolf OddsBoxing OddsMMA OddsNASCAR Odds
Picks, Teasers, Parlays
NFL Free Expert PicksNCAAF Free Expert PicksNCAAB Free Expert PicksNBA Free Expert PicksMLB Free Expert Picks
Sportsbooks
BetMGM ReviewFanDuel ReviewBetRivers ReviewFanatics ReviewRecommended SportsbooksLegal Sportsbooks by State
Resources & Guides
How to bet on NFLHow to bet on NCAAFHow to bet on NBAHow to bet on NCAABHow to bet on SoccerHow to bet on Golf
Trending News
Sports Injury ReportsCasino News

Sports Betting

Sports Betting OffersNFL BettingCollege Football BettingNBA BettingCollege Basketball BettingSoccer BettingLegal States for Betting SportsLegal Sportsbooks for Betting Sports

Online Casinos

Casino OffersCasino NewsBlackjack strategyPoker strategyVideo PokerRoulette strategySlots strategyClassic SlotsBacarrat strategy

Betting Odds & Lines

NFL OddsCollege Football OddsNBA OddsCollege Basketball OddsNHL OddsSoccer OddsGolf OddsBoxing OddsMMA OddsNASCAR Odds

Picks, Teasers, Parlays

NFL Free Expert PicksNCAAF Free Expert PicksNCAAB Free Expert PicksNBA Free Expert PicksMLB Free Expert Picks

Sportsbooks

BetMGM ReviewFanDuel ReviewBetRivers ReviewFanatics ReviewRecommended SportsbooksLegal Sportsbooks by State

Resources & Guides

How to bet on NFLHow to bet on NCAAFHow to bet on NBAHow to bet on NCAABHow to bet on SoccerHow to bet on Golf

Trending News

Sports Injury ReportsCasino News
nfl

NFL Week 13 Parlay: Best bets for Thanksgiving Weekend

Green Bay Packers head coach Matt LaFleur. (Photo by Cody Glenn/Icon Sportswire)

James Scully headshot
James Scully

November 26th, 2025

SHARE

Since 2004, favorites are 40-20 ATS in Thanksgiving Day games, but YouBet.com will take a stand against with a best bet selection in our Week 13 parlay. We hit the Week 12 parlay, the third win over the last six weeks. And after studying the games, YouBet.com offers the following Week 13 parlay, all lines courtesy of BetMGM and times listed as Eastern Standard Time.

NFL Week 13 Parlay (+621): Packers +2.5 - Under 44.5 (Bears-Eagles) - Colts -4.5

Packers at Lions, Thursday, 1 p.m.

The Packers are an underdog for the first time since losing to the Eagles in last year’s playoffs, and Matt LeFleur has compiled a 24-13-1 ATS record (64.5%) as an underdog, easily the top mark among active coaches. And with a 20-18 straight-up record, LeFleur is the only coach in the Super Bowl era to post a winning record as an underdog. The Lions are slumping, with the offensive line struggling during a 16-9 loss to the Eagles two games back, and then trailing to the Giants 27-17 in the fourth quarter before rallying dramatically to win in OT last week. The Packers defense (top five in most categories) gets after the quarterback. After going through a two-game slide earlier this month, scoring only 20 combined points in consecutive losses, Green Bay’s offense is back on track (50 combined points in the last two games). Give us the Pack on the upswing.

Pick: Packers +2.5

Bears at Eagles, Friday, 3 p.m.

No faith in high-scoring output from dysfunctional Eagles offense, but can’t recommend injury-riddled Bears defense. Or a Chicago offense that has a negative 3-point differential on the season despite being 8-3, recording five wins while trailing in the fourth quarter. Bears have yet to beat a team with a winning record, and this looks like a good bounce-back spot for an Eagles defense that surrendered nearly 500 yards to Dallas last week. The Eagles will look to get their rushing attack going – they’ll need it vs better teams down the road – an expected low-scoring affair.

Pick: Under 44.5

Texans at Colts, Sunday, 1 pm.

The Texans moved past .500 with their fourth win in the last five games last week, defeating the Bills at home. But they haven’t played well on the road, the lone win over the last seven weeks being an ugly 16-13 victory at Tennessee, and Texas is the lowest scoring team in the league with a winning record (22.1 points per game), entering with a poor 44.1% red zone efficiency rate (31st). The Colts exit an overtime loss at Kansas City, where they played arguably as well as Houston has all season, and Indy has been better at home. The Colts top the NFL in scoring (31 points per game) and rank 3rd in red zone efficiency (66.7%). One weakness for the Texans' formidable defense has been explosive runs, and Jonathon Taylor can exploit. The Texans won’t be able to match points as the Colts get back on track following a pair of losses in the last three games.

Pick: Colts -4.5

ADVERTISEMENT

ADVERTISEMENT

NFLYouBet

Suggested Articles

NFL Week 13 Parlay: Best bets for Thanksgiving Weekend

Kansas City Chiefs tight end Travis Kelce (87) kisses girlfriend Taylor Swift as he celebrates winning the game during Super Bowl LVIII between the Kansas City Chiefs and the San Francisco 49ers.

Missouri sports for winning bets, launching on December 1st

NFL Week 12 Parlay: Ravens working back into playoff picture

ADVERTISEMENT

Colorado

Bet $5 Get $300 in Bonus Bets If Your Bet Wins!

21+ (18+ D.C.) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call  1-800-GAMBLER or visit RG-help.com. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800)-327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8-HOPENY or text HOPENY (467369) (NY).

Fanatics Sportsbook logo

Bet $10 Get $100 In FanCash + Up To $100 Back In FanCash Every Football Gameday

New Customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, NY, OH, PA, TV, VA, VT, WV, WY. Must apply this Promotion in your bet slip and place a $1+ cash wager with odds of - 500 or longer each day for 10 straight days to be eligible for the Rewards each day. Your 10 days begin the day you establish your account. Wager must settle as a loss to qualify for FanCash. FanCash will equal the amount of the losing wager(s) (up to $100 in FanCash per day). See Fanatics Sportsbook & Casino App for FanCash terms and full promo. terms.

Get up to $1,500 Back in Bonus Bets If You Don't Win

21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). First Bet Offer token will expire seven (7) days after being issued. Limit one offer per customer. Subject to eligibility requirements. Bonus bets are non-withdrawable. Gambling Problem? Call 1-800-GAMBLER.

Welcome to YouBet™, your daily destination to read the latest news and stories on sports, sports betting, gambling, wagering, and games of chance.

Bet on Sports

NFL BettingCollege Football BettingNBA BettingCollege Basketball BettingSoccer BettingGolf BettingBoxing BettingMMA BettingNASCAR Betting

How to Bet on Sports

How to bet on NFLHow to bet on NCAAFHow to bet on NBAHow to bet on NCAABHow to bet on SoccerHow to bet on Golf

Online Sports Betting

Sportsbook OffersSports Betting OddsSportsbooks by StateExpert Picks for SportsSportsbook OperatorsOnline Horse Betting Offers

About

Terms & ConditionsPrivacy & SecurityCookie PreferencesWager ResponsiblyDo Not Sell or Share My InfoAbout Us

Copyright © Churchill Downs Technology Initiatives Company, All Rights Reserved. This site is solely for entertainment purposes and does not contain any real money wagering. YouBet.com does not promote betting or wagering to users under the relevant legal age in their jurisdiction. Online gambling is not legal in some jurisdictions. Prior to wagering online, it is your responsibility to review local regulations. We encourage responsible gaming and provide resources for individuals who may (or know someone who may) have a gaming addition. Churchill Downs Technology Initiatives Company and its affiliates, officers, directors, and employees do not take responsibility for your actions.

Content intended for a 21+ audience. Gambling Problem? Call 1-800-Gambler or find assistance with the National Council on Problem Gambling.