NFL Week 17 Parlay: Eagles face key test at Bills

Plenty remains up for grabs with two weeks left in the 2025 NFL regular season. In the AFC, Denver (12-3), New England (12-3), Jacksonville (11-4), Chargers (11-4), and Buffalo (11-4) are battling for the top seed and first-round bye, and none have locked up their respective divisions.

The NFC West race promises to be fascinating, with Seattle (12-3) leading the way and the Niners (11-4) and Rams (11-4) lurking. Chicago (11-4) is still in the mix for the top seed while opening a two-game advantage in the NFC North, and Carolina (8-7) has taken the pole position from Tampa (7-8) in a lowly NFC South.

YouBet.com will recommend the following best bets in a Week 17 parlay, all lines courtesy of BetMGM and times listed as Eastern Standard Time.

NFL Week 17 Parlay (+595): Under 39.5 (Texans-Chargers) - Dolphins +5.5 - Eagles +2

Texans at Chargers, SoFi Stadium, Saturday, 4:30 p.m.

The Texans' offense has been efficient since C.J. Stroud returned from injury, averaging 27.7 points over the last three games. And despite the lack of a home-field atmosphere, the Chargers have been excellent at SoFi, defeating the Eagles, the Steelers in recent weeks, and the Broncos earlier in the season. They exit a strong showing, recording 452 total yards in a dominant win at Dallas, and have the balance to present problems to a Texans team that is only 4-3 straight up on the road this year. Both defenses are top-notch, but the total is too low for a pair of offenses in good form.

Pick: Over 39.5

Buccaneers at Dolphins, Hard Rock Stadium, Sunday, 1 p.m.

The Buccaneers opened 5-1, defeating the Seahawks and the Niners in back-to-back weeks, but since Baker Mayfield got injured in a Week 7 loss to the Lions, they’ve slipped to 7-8, losing six of the last seven games. Mayfield won’t be healthy until the offseason, posting a negative EPA (expected points added) in seven of the last eight games, and the Buccaneers remain overvalued. Dolphins had offensive success in Quinn Ewers’ first start, but turnovers cost them a viable chance to win in a misleading final score. Look for them to show more against a declining Buccaneers team that shouldn’t be favored, entering on a 0-7 ATS slide.

Pick: Dolphins +5.5

Eagles at Bills, Highmark Stadium, Sunday, 4:25 p.m.

Favorable match-up for the Eagles, who are running the ball effectively late in the season and face a 30th-ranked Bills run defense that has allowed 156 rushing yards per game in the last three. Eagles own the NFL’s top-ranked defense in December, with opponents averaging only 190 total yards in the last three games, and they’ve quietly gained nearly 800 total yards in the last two games, displaying outstanding balance as the offense comes together at the right time of year. Bills have been living right the last three weeks, pulling out tight games that could’ve gone either way against the Bengals, Patriots, and Browns, but their luck runs out Sunday.

Pick: Eagles +2