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NFL Week 18 Parlay: Seahawks-Niners Showdown for Top Seed

San Francisco 49ers quarterback Brock Purdy (13) (Photo by Nick Wosika/Icon Sportswire)

James Scully headshot
James Scully

December 31st, 2025

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Top seeds in both conferences, as well as four divisional races, remain unresolved entering the final week of the NFL regular season, and YouBet.com will include a pair of big games among its best bets in a Week 18 parlay. All lines courtesy of BetMGM; times listed as Eastern Standard Time.

Week 18 Parlay (+606):  Niners Moneyline  -102;Under 36.5 (Packers-Vikings) - Steelers +3.5

Seahawks at Niners, Levi’s Stadium, Saturday, 8 p.m.

Niners exit a dynamic offensive effort vs Bears, accumulating nearly 500 total yards as Brock Purdy delivered arguably his best career performance and led a late touchdown-winning drive. San Fran hopes to have George Kittle and Trent Williams back in the fold. The Seahawks revved up the defensive intensity at Carolina last week, allowing only 139 net yards in a dominant win, but Sam Darnold wasn’t sharp, completing 18 of 27 passes for a touchdown and an interception, and has tossed at least one interception in each of the last four games. Matt Stafford had success against Seattle’s secondary two games back, and no offense is performing at a higher level right now than the Niners, who have averaged 42.3 points over the last three contests. We’ll side with offense.

Pick: Niners Moneyline -102

Packers at Vikings, U.S. Bank Stadium, Sunday, 1 p.m.

The public will gravitate toward the over on this low total, but we’ll go the other way due to the quarterback situations. Vikings exit a win over mistake-filled Lions, but Max Brosmer was not effective, completing nine of 16 passes for 51 yards. It has not worked out for the Vikings' third-string quarterback. The Packers, who will rest most of their starters with playoff seeding locked up, may be down to third-string Clayton Tune due to Malik Willis’ shoulder injury last week. It's tough to envision them moving the ball against the Vikings’ first-team offense and projecting an ugly, low-scoring game.

Pick: Under 36.5

Ravens at Steelers, Acrisure Stadium, Sunday, 8:20 p.m.

The Steelers held Derrick Henry to 94 rushing yards on 25 carries (3.8-yard average) a month ago and will have a defensive plan to slow the Ravens’ only offensive option. Baltimore has only 308 passing yards over the last three games, Lamar Jackson isn’t healthy, and Tyler Huntley must rely on short passes. The Steelers have the edge at quarterback with Aaron Rodgers despite a banged-up or suspended receiving corps. The underdog is 30-12-3 ATS in the series since 2005, and when the line is 3+ points, underdogs are 24-5-3 ATS. These rivals know each other well. The Steelers will employ a backs-against-the-wall mentality, with everyone doubting them after last week, and it figures to be another hard-fought, close affair that could easily be settled by a field goal or less.

Pick: Steelers +3.5

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