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NFL Week 10 Parlay: Packers seek to bounce back in pivotal NFC matchup

Wed Nov 05 2025James Scully

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NFL Week 9 Parlay: Colts face difficult road test, Seahawks return off bye

Wed Oct 29 2025James Scully

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NFL Week 8 Parlay: Important home tests for Eagles, Ravens

Wed Oct 22 2025James Scully

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NFL Week 7 Parlay: Jaxson Dart and Giants travel to Mile HighNFL Week 6 Parlay: Jags host road-savvy Seahawks on short rest
NFL ball placed on a football field near the yardline.

NFL ball placed on a football field near the yardline. (Photo courtesy of Shutterstock)

NFL Week 8 Parlay: Important home tests for Eagles, Ravens

Wed Oct 22 2025James Scully

After analyzing the betting board, YouBet.com will look to stay hot with the following Week 8 NFL parlay.

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A general view of the goal posts at Invesco Field at Mile High in Denver, CO. (Photo by John McDonough/Icon Sportswire)

NFL Week 7 Parlay: Jaxson Dart and Giants travel to Mile High

Wed Oct 15 2025James Scully

YouBet.com scours the NFL slate each week for a three-team parlay and will recommend the following parlay for Week 7.

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Close up of an NFL football with the NFL logo.

Close up of an NFL football with the NFL logo. (Photo courtesy of Shutterstock)

NFL Week 6 Parlay: Jags host road-savvy Seahawks on short rest

Wed Oct 08 2025James Scully

After hitting its Week 5 parlay, YouBet is back to provide a parlay pick for Week 6 of the 2025 NFL regular season.

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NFL Week 5 Parlay: Rookie road test for Giants, Eagles face defensive stalwart

Wed Oct 01 2025James Scully

YouBet.com has scoured the slate and selected the following parlay in Week 5 of the 2025 NFL regular season.

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CINCINNATI, OH - SEPTEMBER 23: Washington Commanders helmets sit during the game against the Washington Commanders and the Cincinnati Bengals on September 23, 2024, at Paycor Stadium in Cincinnati, OH.

CINCINNATI, OH - SEPTEMBER 23: Washington Commanders helmets sit during the game against the Washington Commanders and the Cincinnati Bengals on September 23, 2024, at Paycor Stadium in Cincinnati, OH. (Photo by Ian Johnson/Icon Sportswire)

Week 4 NFL Parlay Play: Commanders buoyed by strong defense in Daniels’ absence

Wed Sep 24 2025James Scully

Week 4 of the NFL regular season features plenty of intriguing games, and YouBet has selected three wagers for a parlay pick below.

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Close up of an NFL football with the NFL logo.

Close up of an NFL football with the NFL logo. (Photo courtesy of Shutterstock)

Odds to Win NFC West in NFL 2025-26 Season

Wed Sep 24 2025YouBet Staff

Explore the latest odds to win the NFC West, with insights on division trends, betting shifts, and key factors shaping the race this season.

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Nfl branded football. (Photo courtesy of Shutterstock)

Odds to Win NFC North in NFL 2025/2026 Season

Wed Sep 24 2025YouBet Staff

Explore the latest odds to win the NFC North, with insights on division trends, betting shifts, and key factors shaping the race this season.

NFL

Close up of football threads.

Close up of football threads. (Photo courtesy of Shutterstock)

Odds to Win NFC East in NFL 2025-26 Season

Wed Sep 24 2025YouBet Staff

Explore the latest odds to win the NFC East, with insights on division trends, betting shifts, and key factors shaping the race this season.

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Arizona Cardinals quarterback Kyler Murray looks to throw. (Photo by Jordon Kelly/Icon Sportswire)

NFL Week 3 Parlay: Early-season showdown between heated NFC West rivals

Wed Sep 17 2025James Scully

After a thorough review of the NFL Week 3 slate, YouBet.com offers its best parlay bet.

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NFL ball placed on a football field near the yardline.

NFL ball placed on a football field near the yardline. (Photo courtesy of Shutterstock)

NFL Week 2 Best Bets: Bills travel to Jets following dramatic comeback win

Wed Sep 10 2025James Scully

After an opening week punctuated by dramatic comeback wins, Week 2 of the 2025 NFL season promises to be exciting, and YouBet.com provides best bet selections!

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Football in the stadium.

Football in the stadium. (Photo courtesy of Shutterstock)

Top 5 Bet Types for Beginner NFL Bettors

Fri Sep 05 2025YouBet Staff

New to NFL betting? Discover the top 5 bet types every beginner should know, with simple tips to start wagering smarter in 2025.

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Football on a football field with the goal post in the background.

Football on a football field with the goal post in the background. (Photo courtesy of Shutterstock)

Over/Under Football Betting Explained: 2025 Guide to Betting Totals

Fri Sep 05 2025YouBet Staff

Over/Under football betting explained in our 2025 guide. Learn how totals work, key strategies, and tips to bet smarter this season.

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NFL football (Photo courtesy of Shutterstock)

NFL Underdog Betting Strategy: How to Profit Against Favorites

Fri Sep 05 2025YouBet Staff

Master NFL underdog betting strategy with tips to profit against favorites, spot value lines, and win more this 2025 season.

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NFL Football Betting News, Analysis, and Predictions

The Basics of Betting on NFL Football

National Football League (NFL) betting includes the moneyline, spread and total. Exotic bets such as parlays and round robins are also available. The spread in football is known as the "betting line." Futures wagering and prop bets are also extremely popular among football enthusiasts. With 17 games played by every team during a 18-week period, for a total of 272 regular season NFL games, there are plenty of opportunities for action. Learn how to make the best NFL bets and how to bet on NFL games by clicking on the links below.

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Free NFL Expert Picks

Get free news and analysis from YouBet.com's NFL Experts that will help you make smarter bets on football this season.

NFL Moneyline Betting

Betting on an NFL moneyline is pretty straightforward as you're simply picking the winning team. In most cases, there will be a favorite and an underdog listed for each game. Placing a bet on the favorite will offer a lower payout while placing a bet on an underdog will offer a premium payout. The NFL moneyline is typically listed based on the bet required to win $100 if betting on the favorite vs. the potential win for a bet of $100 placed on the underdog.

In addition to current records and which team is at home, the starting quarter back typically has a big impact on NFL moneylines. If the team leader of the team is on the field for the underdog, that might even up the odds a bit between two teams that might seem otherwise a bit mismatched.

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Betting NFL Against the Spread

In addition to moneylines, NFL matches will also feature a spread or "betting line" between two teams. Rather than simply picking a winner, this form of betting features a 1.5 spread on the final score of any game.

Betting the NFL spread can be a great option in certain scenarios. For example, if you expect a favored team to win by several touchdowns or field goals, betting the spread will get you better odds than going with the traditional moneyline.

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NFL Over/Under Bets

Let's say two teams seem evenly-matched, but the starting quarter back is not very good, and you expect a high number of touchdowns to be scored. In this instance, you may want to consider betting on the "over/under" total for a NFL game, rather than picking a winner.

An NFL over/under bet involves simply choosing whether you think there will be more total points scored by both teams, or less total scores, than what is listed on the published line.

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NFL Futures and NFL Prop Betting

The futures market for the NFL will feature heavily on the Super Bowl, division titles, conference championships and other milestones like MVP and Coach of the Year. These are long term investments. The Super Bowl favorite usually begins around +500 and ends around +300 by the time the playoffs begin. A longshot would be any team that has +2000 odds to win the Super Bowl or higher.

More Info on NFL Futures and Prop Bets

Prop betting is one of the best parts about football betting. You can generate action on player props and team props. You can bet on almost anything these days from total rushing yards by a particular player, to total number of first down in an over/under fashion. This has added a certain level of extra joy to betting on American football.

By far the most popular futures market is the Regular Season Win Totals presented in preseason. These measure how many wins a team will have at the end of Week 17 and give odds for OVER and UNDER that total.

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NFL Betting Explained: How to Bet on NFL Games

5 Stats to lean on for betting NFL Football

Using negative stats to your advantage while betting the nfl

The NFL Spread, NFL Moneyline and NFL TOTAL

You've come to the right place to have NFL Betting explained. Like all major sports, American football betting is built around the straight bets - the spread, moneyline and total. The spread is a point differential between the two teams that indicates a favorite being handicapped against an underdog. This is to account for the strengths of either team. If you were to wager on Team A at -6.5 against Team B, you would need Team A to win by at least seven points to clear the wager. Inversely, Team B could win outright or lose by up to six points in order for your bet to cover.

The moneyline is a bet on the outright winner, while the total is an over/under wager on the total number of points scored the game itself.

The natural home line for NFL and NCAAF betting is -3.0, while the total will begin at 44.5. From there, the odds are adjusted to account for the disparity between the two sides. Action generated from the betting public can also influence the odds in a game.

American football uses American odds, but you can also adjust the system at various sportsbooks to view decimal or fractional odds if you prefer. Wagers with a minus-sign will indicate how much you have to bet in order to win $100. An example is a -135 favorite ($135 bet to win $100). Underdogs will have a plus-sign in front of their odds, indicating how much you would win if you bet $100. An example is +275 ($275 return on $100 wager).

Parlays and straight bets both apply to American football betting and gain extra traction because most of the games all happen on the same day. You can also enjoy teasers, if-bets and round robins. Many sportsbooks offer a full menu when it comes to football betting every weekend!

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NFL Information and History

When it comes to sports betting in the United States, nothing is bigger than NFL football.

The National Football League was founded in 1920 and has survived many years of instability and competition from rival organizations to become the strongest American professional football league. The NFL completed a merger with the American Football League (AFL) in 1970 to create a 26-team circuit. Since then, the league has expanded four times and added six new franchises to create today’s modern NFL with 32 teams.

The NFL is governed by a commissioner, and the schedule consists of a 17-game regular season with each team playing 16 games and having one bye week. The regular season runs from September through December.

Following the regular season, six teams from each conference qualify for the playoffs with each division winner plus two wild cards participating. The winner of each conference plays in the Super Bowl for the league’s top prize, the Vince Lombardi Trophy.

The NFL has the highest average attendance at their games of any professional sports league in the world. Attendance averaged more than 67,000 fans per game in 2017. You can learn more about the NFL at http://www.NFL.com.

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Where Can I Bet on NFL Games Legally?

Residents of most states can bet legally on NFL games at a variety of sportsbooks. You'll find a wide selection of odds, props, and futures to wager on throughout the NFL season and beyond! And don't forget to visit YouBet.com regularly for the best NFL betting advice from our team of experts.

NFL Betting Strategy

YouBet.com is your one-stop source for the best NFL betting strategy on the Web. Check out our weekly betting guides, discover Super Bowl betting trends, and learn how to bet on the Super Bowl with expert tips and tricks from our featured columnists. 

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NFL Week 7 Parlay: Jaxson Dart and Giants travel to Mile HighNFL Week 6 Parlay: Jags host road-savvy Seahawks on short restNFL Week 5 Parlay: Rookie road test for Giants, Eagles face defensive stalwartWeek 4 NFL Parlay Play: Commanders buoyed by strong defense in Daniels’ absenceOdds to Win NFC West in NFL 2025-26 Season

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